MovDisordV3, Main, Exploration, bibRecord, 002A52

Telomere Length and Risk of Parkinson's Disease

Identifieur interne : 002A52 ( Main/Exploration ); précédent : 002A51; suivant : 002A53

Telomere Length and Risk of Parkinson's Disease

Auteurs : HAO WANG [États-Unis] ; HONGLEI CHEN [États-Unis] ; XIANG GAO [États-Unis] ; Monica Mcgrath [États-Unis] ; Dwayne Deer [États-Unis] ; Immaculata De Vivo [États-Unis] ; Michael A. Schwarzschild [États-Unis] ; Alberto Ascherio [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0133682

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Télomère, Facteur risque, Etude cas témoin.

English descriptors

KwdEn :
- Case control study, Nervous system diseases, Parkinson disease, Risk factor, Telomere.

Abstract

We investigated whether telomere length was associated with the risk of Parkinson's disease (PD) in a case-control study (96 cases and 172 age-matched controls) nested within the Health Professionals Follow-up Study. Relative ratio of telomere repeat copy number to single-gene copy number in peripheral blood leukocytes was determined by quantitative real time PCR. Men with shorter telomeres had a lower PD risk (multivariate adjusted relative risk for the lowest vs. the highest quartile 0.33; 95% confidence interval: 0.12-0.90). Our results suggest that, contrary to telomere attrition observed in several aging-related diseases, shorter telomeres are not associated with an increased risk of PD.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">We investigated whether telomere length was associated with the risk of Parkinson's disease (PD) in a case-control study (96 cases and 172 age-matched controls) nested within the Health Professionals Follow-up Study. Relative ratio of telomere repeat copy number to single-gene copy number in peripheral blood leukocytes was determined by quantitative real time PCR. Men with shorter telomeres had a lower PD risk (multivariate adjusted relative risk for the lowest vs. the highest quartile 0.33; 95% confidence interval: 0.12-0.90). Our results suggest that, contrary to telomere attrition observed in several aging-related diseases, shorter telomeres are not associated with an increased risk of PD.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Telomere Length and Risk of Parkinson's Disease

Telomere Length and Risk of Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri